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Kalyankar, T. M.
- Reversed-Phase Liquid Chromatographic Method for Simultaneous Determination of Metformin and Repaglinide in Pharmaceutical Preparations
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Authors
Affiliations
1 School of Pharmacy, S.R.T. Marathawada University, Nanded, Maharashtra, IN
2 RTM Nagpur University, Nagpur, MS, IN
1 School of Pharmacy, S.R.T. Marathawada University, Nanded, Maharashtra, IN
2 RTM Nagpur University, Nagpur, MS, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 5 (2011), Pagination: 233-237Abstract
A simple, rapid, precise and accurate reversed phase high performance liquid chromatographic method has been developed for the simultaneous determination of metformin in combination with repaglinide. This method uses a Hypersil ODS C18 (250mm×4.6mm×5μ particle Size) analytical column, a mobile phase of acetonitrile and buffer containing 0.05 M ammonium acetate in the ratio 60:40 (v/v), and pH adjusted to 5.0 with orthophosphoric acid. The instrument was set with a flow rate of 1 ml/min and PDA detector wavelength at 271 nm. The retention times for metformin and repaglinide are 3.13 min and 10.01min respectively. The method was validated as per the ICH guidelines. The linearity range for metformin and repaglinide were found to be 200-1200 and 0.5-3.0 μg/ml respectively. The percentage recovery for metformin and repaglinide are in the range between 99.25-99.48 and 98.58-100.26 respectively. The correlation coefficients of metformin and repaglinide were 0.999, and 0.999, respectively. The relative standard deviation for six replicates was always less than 2%. The statistical analysis proves that the method was suitable for analysis of metformin and repaglinide as a bulk drug and in pharmaceutical formulation without any interference from the excipients.
Keywords
Antidiabetic Drugs, Metformin, Repaglinide, Validation and RP-HPLC.
- Simultaneous Determination of Famotidine and Dicyclomine HCl in combined Tablet Dosage form by UV-Spectrophotometer
Abstract Views :173 |
PDF Views:2
Authors
Affiliations
1 Department of Quality Assurance, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded- 431606, (M.S.), IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, Andhra Pradesh, IN
1 Department of Quality Assurance, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded- 431606, (M.S.), IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, Andhra Pradesh, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 2 (2017), Pagination: 408-413Abstract
A simple, accurate, precise, and specific UV-Vis spectrophotometric simultaneous equation method has been developed for simultaneous determination of famotidine and dicyclomine HCl in its combined tablet dosage form by using methanol as a solvent. The proposed simultaneous equation method involves measurements of wavelength selected at 292 nm for famotidine and 218 nm for dicyclomine HCl. The linearity was found to be in the range of 20-120 μg/ml and 50-100 μg/ml for famotidine and dicyclomine HCl respectively. Beer's law was obeyed in this concentration range with correlation coefficient of 0.998 and 0.999 for famotidine and dicyclomine HCl respectively. The repeatability, Intra-day precision, Interday precision % RSD were found to be 0.140, 0.1305, 0.167 for famotidine and 0.180, 0.0321, 0.0472 for dicyclomine HCl respectively. Limit of detection and quantification was found to be 0.6944 μg/ml and 2.1044μg/ml for famotidine and 0.4446μg/ml for and 1.3474μg/ml for dicyclomine HCl respectively. Assay results for marketed formulation were found to be 98.91% and 101.83% for famotidine and dicyclomine HCl respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of famotidine and dicyclomine HCl in their combined dosage form.Keywords
Famotidine, Dicyclomine Hydrochloride, Simultaneous Equation Method, UV Spectrophotometry and Forced Degradation Study.- Development and Validation of Analytical Method for Estimation of Cetirizine Hydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Formulation
Abstract Views :166 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, (M.S.), IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, Andhra Pradesh, IN
1 Department of Quality Assurance, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, (M.S.), IN
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, Andhra Pradesh, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 50-56Abstract
Analytical method using Fourier transform Infrared Spectroscopy was developed and validated for estimation of cetirizine hydrochloride and phenylephrine hydrochloride in their pharmaceutical formulation. The solid-state samples were prepared by dilution in dry potassium bromide and were analyzed by FTIR Spectrophotometer. A linear relationship for the carbonyl peak area centered around 1741cm-1 was observed in the range of 0.2-1.2% w/w with good correlation coefficient 0.997 for the cetirizine hydrochloride and for the hydroxyl peak area centered around 3419 cm-1 was observed in the range of 0.4-2.4% w/w with good correlation coefficient 0.998 for phenylephrine hydrochloride. The developed method was validated as per ICH guidelines.In addition to this the stability study is carried out by thermal exposure, photolytic exposure and sunlight exposure.Keywords
Cetirizine Hydrochloride, Phenylephrine Hydrochloride, FT-IR, Method Validation and ICH Guideline.References
- Pavia DL, Lampman GM and Kriz GS. Introduction to spectroscopy. 2001; 3rd ed: pp 13-24.
- https://en.wikipedia.org/wiki/Cetirizine.
- Indian Pharmacopoeia Government of India, Ministry of Health and Family Welfare, published by controller of publication, Delhi2007; Vol-II, 267-268.
- Indian Pharmacopoeia Government of India, Ministry of Health and Family Welfare, published by controller of publication, Delhi2007; Vol-III, 143-144.
- Wankhede SB, Lad KA and Chitlange SS. Development and Validation of UV-Spectrophotometric Methods for Simultaneous Estimation of Cetirizine hydrochloride and Phenylephrine hydrochloride in Tablets. International Journal of Pharmaceutical Sciences and Drug Research. 4(3); July-September 2012: 222-226.
- Jaybhaye SS et al. Development and validation of UV Spectrophotometric assay protocol for simultaneous estimation of Paracetamol, Phenylephrine, Cetirizine in combine tablet dosage form using simultaneous equation by matrix method. International Journal Of Drug Formulation And Research. 4(2); Mar-Apr 2013.
- Merukar SS et al. Simultaneous spectrophotometric methods for Estimation of Levocetirizine and Pseudoephedrine in Pharmaceutical tablet dosage form. Journal of Pharmaceutical Sciences and Research, 1(2); 2009: 38-42.
- Sharma D et al. Development and Validation Of Spectroscopic Method For Simultaneous Estimation of Salbutamol Sulphate, Ambroxol Hydrochloride And Cetirizine Hydrochloride In Combined Pharmaceutical Tablet Formulation: A Novel Technique For In - Vitro Dissolution Studies. International Journal of Pharmacy and Pharmaceutical Sciences. 6(11); 2014: 446 – 452.
- Patel MK and Veni KJK. Analytical Method Development and Validation of Cetirizine Hydrochloride and Phenylephrine Hydrochloride in Combined Dosage Form. Journal of Pharmaceutical Sciences and Bioscientific Research. 5 (2); 2015: 180-186.
- Wadher SJ, Kalyankar TM and Panchal PP. Development and Validation of Simultaneous Estimation of Chlorpheniramine Maleate and Phenylephrine Hydrochloride in Bulk and Capsule Dosage Form by Ultra-Violet Spectrophotometry. International Journal of Chem Tech Research. 5(5); July-Sept 2013: 2410-2419.